Ukr.Biochem.J. 2015; Volume 87, #2, March-April

Antioxidant activity of alkoxy derivatives of (quinolinе-4-ylthio)carboxylic acids

O. О. Brazhko1, M. P. Zavgorodny1, O. S. Kruglyak2,
L. O. Omeljanchik1, G. A. Shapoval2

1Zaporizhzhya National University, Ukraine;
2Institute of Bioorganic Chemistry and Petrochemistry,
National Academy of Sciences of Ukraine, Kyiv;
e-mail: hellen.brazhko@gmail.com

A selection of potential bioactive molecules including alkoxy derivatives of (quinoline-4-ylthio)carboxylic acids using virtual screening has been carried out and their biological activity was determined. The studied substances proved to be low-toxic, biologically active compounds. It was established that 4-thio derivatives of quinoline exhibit pronounced antiradical, antioxidant effects and can act as preventive antioxidants, radio and cytoprotectors.

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