Ukr.Biochem.J. 2015; Volume 87, #1, January-February

Mg(2+),ATP-dependent plasma membrane calcium pump of smooth muscle cells. I. Structural organization and properties

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T. O. Veklich, Iu. Iu. Mazur, S. O. Kosterin

Palladin Institue of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;
e-mail: veklich@biochem.kiev.ua; yuliya.vorona@gmail.com

Tight control of cytoplasm Ca2+ concentration is essential in cell functioning. Changing of Са2+ concentration is thorough in smooth muscle cells, because it determines relaxation/constraint process. One of key proteins which control Са2+ concentration in cytoplasm is Mg2+,ATP-dependent plasma membrane calcium pump. Thus, it is important to find compoumds which allowed one to change  Mg2+,ATP-dependent plasma membrane calcium pump activity, as long as this topic is of current interest in biochemical research which regards energy and pharmacomechanical coupling mechanism of muscle excitation and contraction. In this article we generalized literatute and own data about properties of smooth muscle cell plasma membrane Ca2+— pump. Stuctural oganization, kinetical properties and molecular biology are considered.

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